Structural Centrosomal Abnormalities Push Cells toward Invasion

Visualization of numerical centrosomal abnormalities by immunofluorescent staining.

The presence of multiple centrosomes in tumor cells is associated with the formation of multipolar mitotic spindles and results in aneuploidy of both daughter cells. Centrosome amplification is a feature of all cancer cells. We have previously described centrosome amplification in abnormal B cells. Further studies of centrosome amplification in different stages of B lineage development could pr...

Structural abnormalities in neurones.

Non-centrosomal Microtubule Organization in Differentiated Cells

The centrosome consists of a pair of centrioles surrounded by pericentriolar material. During the formation of the mitotic spindle, multi-protein complexes in the pericentriolar material are involved in the nucleation and anchorage of microtubules. In postmitotic cells of many tissues, proteins of the pericentriolar material lose their association with the centrosome and redistribute to various...

Protein Delivery into Plant Cells: Toward In vivo Structural Biology

Understanding the biologically relevant structural and functional behavior of proteins inside living plant cells is only possible through the combination of structural biology and cell biology. The state-of-the-art structural biology techniques are typically applied to molecules that are isolated from their native context. Although most experimental conditions can be easily controlled while dea...

Numerical and structural chromosome abnormalities

| Genetic instability, which includes both numerical and structural chromosomal abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements have received substantial attention, the role of whole-chromosome aneuploidy in cancer is much less well-understood. Here we review recent progress in understanding the roles of whole-chromosome aneuploidy in cancer, including t...